A Preliminary Assessment of Tinospora sinensis on Mice Liver

Abstract Objective A preliminary study was conducted to assess the role of Tinospora sinensis extract on liver in mice normal and lipopolysaccharide (LPS)-induced health-compromised conditions. Method Mice (n = 3–5) were randomly assigned into groups I IV for hepatotoxic studies. Group normal, group II given LPS (6 mg/kg, intraperitoneal [ip]), III T. only (1 g/kg/day 21 days), whereas administered per os [po] days) with mg/kg ip 7th day). V received monocrotaline (MCT) (200 p.o.) only. VI MCT po) ip). VII (500 mg/kg/day po 7 followed by ip) day. Groups used effect + LPS-induced hepatotoxicity model. Results No elevation alanine transaminase (ALT) levels observed treated or compared (vehicle treated) (group I). Elevation ALT (MCT LPS) VII; histopathology showed injury. Pretreatment VII) did not show any reduction elevated levels. Conclusions In assessment, found exhibit neither itself nor potential thwart damage a xenobiotic under test conditions, dosage, duration study.